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Is FROVA® Right For Me?

FROVA is a prescription medicine used to treat migraine attacks in adults. It is in the class of drugs called selective serotonin receptor agonist.23

Who should not take FROVA?

FROVA should only be taken for a migraine headache. Do not use FROVA to treat headaches that might be caused by other conditions. Tell your doctor about your symptoms. Your doctor will decide if you have migraine headaches and if FROVA is right for you.

Do not take FROVA if you have uncontrolled high blood pressure; have heart disease or a history of heart disease; have hemiplegic or basilar migraine (if you are not sure about this, ask your doctor); have had a stroke; have circulation (blood flow) problems; have taken a similar drug (a serotonin receptor agonist) or an ergotamine-type medicine in the last 24 hours; or have any allergic reaction to the tablet.23 You and your doctor should discuss FROVA before you start taking the medicine and at regular checkups.23

What are common side effects of FROVA?

The most common side effects associated with FROVA are dizziness, fatigue (tiredness), headache (other than a migraine headache), paresthesia (feeling of tingling), dry mouth, flushing (hot flashes), feeling hot or cold, chest pain, dyspepsia (indigestion), and skeletal pain (pain in joints or bones).23

Tell your doctor about any symptoms that you develop while taking FROVA. If you feel dizziness or tiredness, take extra care or avoid driving and operating machinery.

In very rare cases, patients taking this class of medicines experience serious heart problems, stroke, or increased blood pressure. If you develop pain, tightness, heaviness, or pressure in your chest, throat, neck, or jaw, contact your doctor right away.

Also contact your doctor right away if you develop a rash or itching after taking FROVA. You may be allergic to this medicine.23

What to do next:

Listen to Sue's story
Talk to your doctor about migraine
Take our migraine quiz

The most common side effects associated with the use of FROVA are dizziness, tiredness, feeling of tingling, hot flashes, headache (other than migraine headache), dry mouth, hot or cold sensation, pain in joints or bones, chest pain, and indigestion.
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  2. American Council for Headache Education. Headache diary. Available at: http://www.achenet.org/resources/diary.php. Accessed February 21, 2007.
  3. National Headache Foundation. Serotonin. Available at: http://www.headaches.org/consumer/topicsheets/serotonin.html. Accessed February 21, 2007.
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  5. American Council for Headache Education. Migraine and coexisting conditions. Available at: http://www.achenet.org/news/macc.php. Accessed February 21, 2007.
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  7. MacGregor EA. Oestrogen and attacks of migraine with and without aura. Lancet Neurol. 2004;3:354-361.
  8. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001;41:646-657.
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  10. Dzoljic E, Sipetic S, Vlajinac H, et al. Prevalence of menstrually related migraine and nonmigraine primary headache in female students of Belgrade University. Headache. 2002;42:185-193.
  11. Granella F, Sances G, Allais G, et al. Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres. Cephalalgia. 2004;24:707-716.
  12. Couturier EGM, Bomhof MAM, Knuistingh Neven A, van Duijn NP. Menstrual migraine in a representative Dutch population sample: prevalence, disability and treatment. Cephalalgia. 2003;23:302-308.
  13. MacGregor EA, Hackshaw A. Prevalence of migraine on each day of the natural menstrual cycle. Neurology. 2004;63:351-353.
  14. Martin VT, Wernke S, Mandell K, et al. Defining the relationship between ovarian hormones and migraine headache. Headache. 2005;45:1190-1201.
  15. MacGregor EA, Frith A, Ellis J, Aspinall L, Hackshaw A. Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen. Neurology. 2006;67(72):2154-2158. doi: 10.1212/01.wnl.0000233888.18228.19.
  16. Silberstein SD, Elkind AH, Schreiber C, Keywood C. A randomized trial of frovatriptan for the intermittent prevention of menstrual migraine. Neurology. 2004;63:261-269.
  17. Silberstein SD. Practice parameter: Evidence-based guidelines for migraine headache (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2000; 55:754-762.
  18. Cady R, Elkind A, Goldstein J, Keywood C. Randomized, placebo-controlled comparison of early use of frovatriptan in a migraine attack versus dosing after the headache has become moderate or severe. Curr Res Med Opin. 2004; 20(9):1465-1472. doi: 10.1185/030079904x2745.
  19. FROVA® [package insert]. Chadds Ford, PA: Endo Pharmaceuticals; 2007.
  20. Kelman L. Pain characteristics of the acute migraine attack. Headache. 2006;46(6):942-953. doi:10.1111/j.1526-4610.2006.00443.x.
  21. Malik SN, Hopkins M, Young WB, Silberstein SD. Acute migraine treatment: patterns of use and satisfaction in a clinical population. Headache. 2006;46(5):773-780. doi:10.1111/j.1526-4610.2006.00437.x.
  22. Guidelines for controlled trials of drugs in migraine. First edition. International Headache Society Committee on Clinical Trials in Migraine. Cephalalgia. 1991;11(1):1-12.
  23. FROVA® Patient Product Information. Chadds Ford, PA: Endo Pharmaceuticals; 2007.
     

    Important Safety Information

    For more information, please see Full Prescribing Information for FROVA at http://www.frova.com/pi.